Name: Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions (en Inglés)
Price: 2539.92 MXN
Availability: InStock
Author: Yan Shan, Ang
ISBN: 9789811347450

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portada Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions (en Inglés)

Formato

Libro Físico

Autor

Ang Yan Shan

Editorial

Springer

Idioma

Inglés

N° páginas

188

Encuadernación

Tapa Blanda

Dimensiones

23.4 x 15.6 x 1.3 cm

Peso

0.34 kg.

ISBN13

9789811347450

Categorías

Nanotecnología
Química industrial e ingeniería química
Ciencias de la computación

Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions (en Inglés)

Ang Yan Shan (Autor) · Springer · Tapa Blanda

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Origen: Estados Unidos (Costos de importación incluídos en el precio)

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Reseña del libro "Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions (en Inglés)"

This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules - a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally - which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.