Name: Stabilization of Drug Nanocrystals Using Fibroin: Formulation & Evaluation of Drug Nanocrystal and Stabilize Using Fibroin (en Inglés)
Price: 1359.31 MXN
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Author: Rani Dhole; Neha Desai; Jyoti Admuthe
ISBN: 9786202515092

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portada Stabilization of Drug Nanocrystals Using Fibroin: Formulation & Evaluation of Drug Nanocrystal and Stabilize Using Fibroin (en Inglés)

Formato

Libro Físico

Editorial

Lap Lambert Academic Publishing

Autor

Rani Dhole; Neha Desai; Jyoti Admuthe

Año

2020

Idioma

Inglés

N° páginas

112

Encuadernación

Tapa Blanda

ISBN13

9786202515092

Categorías

Cuestiones generales de la medicina

Stabilization of Drug Nanocrystals Using Fibroin: Formulation & Evaluation of Drug Nanocrystal and Stabilize Using Fibroin (en Inglés)

Rani Dhole; Neha Desai; Jyoti Admuthe (Autor) · Lap Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Stabilization of Drug Nanocrystals Using Fibroin: Formulation & Evaluation of Drug Nanocrystal and Stabilize Using Fibroin (en Inglés)"

Nanocrystals of the poorly water-soluble drugs is a promising strategy. To stabilize the drug nanocrystals, stabilizers are usually used; however, the use of common stabilizers is limited by weak stabilization effect and toxicological concerns for long-term treatment. The present work was aimed to investigate the potential of natural silk protein as novel stabilizer for nanocrystal of hydrochlorothiazide, which was a model drug. The nanocrystals of drug with hydrophobic protein stabilizer were prepared by antisolvent precipitation method.Prepared nanocrystals were evaluated for parameters like particle size, zeta potential, DSC, XRD, %crystallinity, SEM, drug content and in vitro dissolution test. Stabilization efficiency of nanocrystals was assessed by their % crystallinity for 3 months. Optimized batch R2 has shown smaller particle size, highest drug content and drug dissolution. Nanocrystals has shown the extended release due to coat of fibroin around the hydrochlorothiazide. From the % crystallinity study it was found that there was not significant change in the nanocrystals prepared using fibroin. So, it was concluded that the fibroin is good stabilizer for drug nanocrystals.