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Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)
Nirmal Singh
(Autor)
·
Jatinder Singh
(Autor)
·
Dhandeep Singh
(Autor)
·
LAP Lambert Academic Publishing
· Tapa Blanda
Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés) - Singh, Jatinder ; Singh, Nirmal ; Singh, Dhandeep
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Origen: Estados Unidos
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Reseña del libro "Synthesis and Biological Evaluation of Mast Cell Stabilizers (en Inglés)"
The role of mast cells can be protective or harmful: depending upon the physiological/pathological condition in which they get activated. The latter role is due to mast cell degranulation and the release of an array of incendiary mediators. Mast cells have a well-established role in diseases like allergy, eczema, anaphylactic shock, mastocytosis, and other miscellaneous mast cell disorders. The derivatives of spiro-β-carboline were evaluated for mast cell stabilization activity by compound 48/80 induced degranulation histamine release assay. The mast cell stabilization of 2′-Heptyl-2′,3′,4′,9′-tetrahydrospiro[cyclohexane-1,1′-pyrido[3,4-b]indole]-3′-carboxylic acid (IC50 = 0.389 0.015 μM) and 2′-Benzoyl 2′,3′,4′,9′-tetrahydrospiro[cyclohexane-1,1′-pyrido[3,4-b]indole]-3′-carboxylic acid (IC50 = 00.469 0.032 μM) compounds were to be of similar potency as that of standard drug sodium cromoglycate (IC50 =0.489 0.003μM).
