Name: Synthesis and Biological Evaluation of Some New Oxadiazole Analogues (en Inglés)
Price: 1366.19 MXN
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Author: Kulkarni, Vivek ; Kumar G. P., Senthil
ISBN: 9786200211453

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portada Synthesis and Biological Evaluation of Some New Oxadiazole Analogues (en Inglés)

Formato

Libro Físico

Autor

Vivek Kulkarni

Senthil Kumar G. P.

Editorial

LAP Lambert Academic Publishing

Idioma

Inglés

N° páginas

116

Encuadernación

Tapa Blanda

Dimensiones

22.9 x 15.2 x 0.7 cm

Peso

0.18 kg.

ISBN13

9786200211453

Categorías

Química

Synthesis and Biological Evaluation of Some New Oxadiazole Analogues (en Inglés)

Vivek Kulkarni (Autor) · Senthil Kumar G. P. (Autor) · LAP Lambert Academic Publishing · Tapa Blanda

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Reseña del libro "Synthesis and Biological Evaluation of Some New Oxadiazole Analogues (en Inglés)"

Many commonly used antibiotics are becoming less effective against infections due to the emergence of microbial resistanceIn case of infection, there is an occurrence of increasing fungal infection from day to day. These fungal infections continue to grow rapidly. Present antifungal agents do not satisfy the medical need.So, antimicrobial agents are of interest for most researchers. Heterocyclic compounds like 1, 3, 4-oxadiazole, quinazoline and dihydropyrimidone nucleus possess a diversity of biological activity. 1, 3, 4-oxadiazole chemistry with a broad spectrum of medicinal value has got much significance in recent years.Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction with carbon disulphide (CS2) gives substituted oxadiazole thione which on reaction with different halides in the presence of dimethylformamide (DMF) give oxadiazole thiones analogs 6a-6c. Structural assignments of these compounds have been made by elemental analysis, UV, IR, 1H NMR, and mass spectral data.